Launch of ZYMEVOLVER 2.0

ZYMVOL releases ZYMEVOLVER 2.0, a new generation of enzyme engineering software.

Obtaining Improved Enzyme Variants without Structural Data


How we obtained improved variants of an enzyme (through in silico modeling) without structural data

In August 2020 we started a collaboration with a customer from the Biotech sector who wanted to increase the activity and specificity of an enzyme for a target substrate.

However, we were facing an outstanding situation. Our customer’s project enzyme had:

  • No known crystal structure
  • Very few known sequences similar to the wild-type, hindering the use of sequence-based tools
  • Unavailability of appropriate templates to build a good quality homology model

Download the PDF to find out how we approached this challenge.

Download Case Study