Expanding our enzyme search platform [CASE STUDY]

CASE STUDY

Expanding our enzyme search platform

BIOMATCHMAKER® (BMM), our proprietary enzyme search software, was first designed as a minimal viable product (MVP) to explore the enzymatic landscape of several alcohol dehydrogenases (ADH), with the aim to identify novel ADHs enzymes able to convert industrially relevant alcohol to corresponding ketones/aldehydes.

However, other relevant industrial processes requiring more complex and sophisticated enzymatic mechanisms remained elusive to our algorithm.

Would we be able to conduct an optimization of the BMM algorithm for it to work with any enzyme family, regardless of the complexity of their reaction? Moreover, would we be able to apply the BMM optimized version to discover new enzymes and expand the company’s pipeline?

To delimit the problem, we focused our efforts into…

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    Press Release IDEA-PS project presentation

    ZYMVOL and CYGYC BIOCON join forces to develop a new computational platform capable of identifying sustainable enzyme inhibitors for detergent formulations


    CYGYC BIOCON and ZYMVOL start collaboration to improve sustainability of detergent formulation

    COMPANY NEWS

    CYGYC BIOCON and ZYMVOL start collaboration to improve sustainability of detergent formulation

    At ZYMVOL we’ve joined forces with biochemical company CYGYC BIOCON, through its BIOKATAL brand, to develop a new generation of sustainable detergents. The project, which has received funding from ACCIÓ’s Tecniospring INDUSTRY programme, aims to improve the performance of enzymes in detergent formulations to facilitate a transition towards more eco-friendly household solutions.

    Most detergent formulations contain enzymes, which are catalytic proteins used to eliminate different types of stains. For the formulation to work properly, enzymes must be deactivated or in a very low activity state, and only activated once they come into contact with water.

    This is especially important when it comes to proteases, an enzyme type that tends to degrade all other enzymes in detergent formulas. To maintain them in the mentioned low activity state when the detergent is not being used or under storage conditions, they need to be deactivated with what are known as «inhibitors».

    Currently, the majority of protease inhibitors used in detergents are compounds based in boron.

    Despite these inhibitors complying with strict European laws, they can still have a negative impact on the environment due to its toxicity towards some types of plants and insects. That’s why CYGYC BIOCON is committed to further improving the sustainability of its product line by eliminating the need for boron-based inhibitors.

     

    «With this project we continue working to offer ecological and sustainable washing solutions. This brings us a little closer to the milestone of obtaining environmentally neutral impact detergents»
    Dr. Sergi Abad, Biotechnology Technical Manager at CYGYC BIOCON

     

    By combining CYGYC BIOCON’s extensive experience in detergent formulations and ZYMVOL’s enzyme engineering know-how, both companies expect their innovation to lead to a much less contaminating solution that affects every household.

    Sustainable Detergents powered by Technology

    Under the name IDEA-PS: Inhibition of Detergent Enzymes Advanced Prediction Software, the project will consist in the development of a new computational platform – named ZYMEVOLVER-iDET – capable of identifying new, sustainable enzyme inhibitors for detergent formulations.

    Dr. Brian Jimenez-Garcia, Senior Researcher at ZYMVOL, will be the primary investigator leading this project.

     

    «By applying ZYMVOL’s technology, we expect to find inhibitors that can substitute the boron-based ones with greener alternatives. We hope that with this software, we will be able to help scientists make more effective formulations that will save resources, energy and water»
    Dr. Brian Jimenez-Garcia, Senior Researcher at ZYMVOL

     

    With the support of Tecniospring INDUSTRY, a programme powered by the Catalan Agency for Business Competitiveness (ACCIÓ), the IDEA-PS project has an established duration of 2 years and expects to achieve the first results by the end of 2022.

    Thanks to this innovation, both CYGYC BIOCON and ZYMVOL calculate they can achieve a significant decrease in the environmental footprint of current detergents.