
CASE STUDY
Expanding our enzyme search platform
BIOMATCHMAKER® (BMM), our proprietary enzyme search software, was first designed as a minimal viable product (MVP) to explore the enzymatic landscape of several alcohol dehydrogenases (ADH), with the aim to identify novel ADHs enzymes able to convert industrially relevant alcohol to corresponding ketones/aldehydes.
However, other relevant industrial processes requiring more complex and sophisticated enzymatic mechanisms remained elusive to our algorithm.
Would we be able to conduct an optimization of the BMM algorithm for it to work with any enzyme family, regardless of the complexity of their reaction? Moreover, would we be able to apply the BMM optimized version to discover new enzymes and expand the company’s pipeline?
To delimit the problem, we focused our efforts into…
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