Biocatalystsmadeeasier

Evolving enzymes onebyte at a time

Projects

We are continuously innovating and are involved in high-impact R&D projects with international universities, research centers and companies

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Scientific Publications

We are committed to expanding the use of computer simulations for discovery and optimization of new biocatalysts

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Projects

BRAINZYME-2022

BRAINZYME is an Industrial Development project that aims to create a tech platform -zymBrain- capable of developing enzymes, offering new services to clients, serve society and provide a tool for intelligent decision-making.

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Reference: 2021/C005/00150909
Start-End Date: 1 September 2022 - 23 May 2024
Grant Amount: 697,753.65 €
Project Name: ZYMBRAIN

 

 

 

TECNIOSPRING-2021

The ENZIMMO-P project, also known as "Software Development for Biocatalytic Process Optimization", is aimed at upgrading the software used to improve enzymes’ properties, which are later applied to industrial processes.

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Reference: ACE026/21/000082
Start-End Date: 25 July 2022 - 24 July 2024
Grant Amount: 136,205.45€
Project Name: ENZIMMO-P

 

 

TECNIOSPRING-2020-DOGC-8160

The IDEA-PS project aims to develop a new computational platform capable of identifying enzyme inhibitors in complex formulations used in chemical industry. The software will allow us to make more effective formulations that will save resources, energy and water.

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Reference: 3412C2V7T-1
Start-End Date: 1 October 2021 - 31 October 2023
Grant Amount: 135.961,90€
Project Name: IDEA-PS

 

 

H2020-MSCA-ITN-2020

Funded by the European Commission, the BioInspireSensing project is a trans-national network for training PhD students in investigating, building, and producing a new generation of bioinspired implantable sensors of pressure, temperature and acidity. New devices will be made of complex hybrid materials, composed of natural molecules and synthetic biopolymers, with the additional properties of being fully biocompatible and bioresorbable.

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Reference: 955643
Start-End Date: 1 January 2021 - 31 December 2024
Grant Amount: 2,856,013€
Project Name: BIOINSPIRESENSING
Consortium: Polytechnic University of Catalonia (coordinator), University of Teramo, University of Warsaw, 4Dcell SAS, University of Groningen, VIB-KU Leuven, University of Lausanne, ZYMVOL BIOMODELING SL.

 

 

H2020-MSCA-RISE-2018

Funded by European Commission, project goals address current limitations in lignin degradation by generating technological and economical solutions inspired by fundamental research. The project provides a holistic view for the development of biocatalytic processes involved in the valorisation of lignin.

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Reference: 824017
Start-End Date: 1 February 2019- 31 January 2023
Grant amount: 970,000€
Project name: B-ligZymes
Consortium: Universidade Nova de Lisboa, Rijksuniversiteit Groningen, Universita degli studi di Roma Torvegata, Technische Universitaet Braunschweig, MetGen, Inquimae, North Carolina State University, ZYMVOL BIOMODELING SL.

Past projects

Scientific Publications

*Most relevant

  1. Enzyme immobilization studied through molecular dynamic simulations, 2023 – Frontiers in Bioengineering and Biotechnology
  2. Towards design of drugs and delivery systems with the Martini coarse-grained model, 2022 – QRB Discovery
  3. Structure- and computational-aided engineering of an oxidase to produce isoeugenol from a lignin-derived compound, 2022 – Nature Communications
  4. Rational-Guided Improvement of NOV1 Dioxygenase for the Conversion of Lignin-Derived Isoeugenol to Vanillin, 2022 – Biochemistry
  5. Unveiling Molecular Details behind Improved Activity at Neutral to Alkaline pH of an Engineered DyP-type Peroxidase, 2022-CSBJ
  6. Distal Mutations Shape Substrate-Binding Sites during Evolution of a Metallo-Oxidase into a Laccase, 2022-ACSCatal
  7. Computational Enzyme Design at Zymvol, 2022 – Enzyme Engineering
  8. Survey of Current Commercial Enzyme and Bioprocess Service Providers, 2020 – AppBio
  9. The Methionine-Rich Loop of Multicooper Oxidase McoA follows Open-To-Close Transitions with a Role in Enzyme Catalysis, 2020 – ACSCat
  10. *Enhancing thermostability by modifying flexible surface loops in an evolved high‐redox potential laccase, 2019 – AIChE
  11. *Increasing redox potential, redox mediator activity, and stability in a fungal laccase by computer-guided mutagenesis and directed evolution, 2019 – ACSCat
  12. Kauniolide synthase is a P450 with unusual hydroxylation and cyclization-elimination activity, 2018 – NatComm
  13. The ins and outs of vanillyl alcohol oxidase: Identification of ligand migration paths, 2017 – PLOSCompBio
  14. *Oxidoreductases on their way to industrial biotransformations, 2017 – BioAdv
  15. *Molecular Modeling in Enzyme Design, Toward In Silico Guided Directed Evolution, 2017- Book chapter
  16. *Repurposing designed mutants: a valuable strategy for computer-aided laccase engineering – the case of POXA1b, 2017 – CatSciTech
  17. Mapping the Long-Range Electron Transfer Route in Ligninolytic Peroxidases, 2017 – JPCB
  18. *Simulating Substrate Recognition and Oxidation in Laccases: From Description to Design, 2017 – JCTC
  19. Probing the Surface of a Laccase for Clues towards the Design of Chemo‐Enzymatic Catalysts, 2017 – ChemPlusChem
  20. *Re-designing the substrate binding pocket of laccase for enhanced oxidation of sinapic acid, 2016 – CatSciTech
  21. Asymmetric sulfoxidation by engineering the heme pocket of a dye-decolorizing peroxidase, 2016 – CatSciTech
  22. *Computer-Aided Laccase Engineering: Toward Biological Oxidation of Arylamines, 2016 – ACSCat
  23. Rational Enzyme Engineering Through Biophysical and Biochemical Modeling, 2016 – ACSCat
  24. Synthesis of 1-Naphthol by a Natural Peroxygenase engineered by Directed Evolution, 2016 – CBC
  25. Molecular determinants for selective C25-hydroxylation of vitamins D2 and D3 by fungal peroxygenases, 2016 – CatSciTech
  26. **Insights into Laccase Engineering from Molecular Simulations: Toward a Binding-Focused Strategy, 2015 – JPClett
  27. Steroid hydroxylation by basidiomycete peroxygenases: A combined experimental and computational study, 2015 – AEM
  28. Atomic Picture of Ligand Migration in Toluene 4-Monooxygenase, 2014 – JPCB

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