Biocatalystsmadeeasier

Evolving enzymes onebyte at the time

Projects

We are continuously innovating and are involved in high-impact R&D projects with international universities, research centers and companies

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R&D Team

We are committed to expanding the use of computer simulations for discovery and optimization of new biocatalysts

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Projects

H2020-SMEInst-2018-2020-2

Funded by European Commission, project goals are to keep improving the technology with artificial intelligence approaches, to develop a computational pipeline for enzyme kits and to develop proprietary enzymes.

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Reference: 873593
Start-End Date: 1 October 2019 - 30 September 2021
Grant Amount: 1,301,000€
Project Name: UNLOCK-EDD: UNLOCKing next generation computer-guided Enzyme Discovery and Design.

H2020-BBI-JTI-2018

Funded by Bio-Based Industries Joint Undertaking (BBI JU) and the Bio-based Industries Consortium (BIC) the project goal is to develop innovative ways of transforming biomass into added-value bio-aromatics, providing solutions to decouple our economy from fossil feedstocks.

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Reference: 837890
Start-End Date: 1 May 2019- 30 April 2023
Grant amount: 3,900,000€
Project name: SMARTBOX
Consortium: Bio base Europe pilot plant, Rijksuniversiteit Groningen, Universidade Nova de Lisboa, Universita degli studi di Pavia, Katholieke Universiteit Leuven, Ava Biochem, B4plastics, Covestro, Borregaard, Quantis, ZYMVOL BIOMODELING SL.

H2020-MSCA-RISE-2018

Funded by European Commission, project goals address current limitations in lignin degradation by generating technological and economical solutions inspired by fundamental research. The project provides a holistic view for the development of biocatalytic processes involved in the valorisation of lignin.

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Reference: 824017
Start-End Date: 1 February 2019- 31 January 2023
Grant amount: 970,000€
Project name: B-ligZymes
Consortium: Universidade Nova de Lisboa, Rijksuniversiteit Groningen, Universita degli studi di Roma Torvegata, Technische Universitaet Braunschweig, MetGen, Inquimae, North Carolina State University, ZYMVOL BIOMODELING SL.

NEOTEC

Funded by The Centre for the Development of Industrial Technology (CDTI), a Spanish public organization under the Ministry of Economy and Competitiveness, project goals is to promote R&D for the improvement of proprietary enzyme search platform by fitting experimental data with in silico predictions.

 

Reference: SNEO-20181226
Start-End Date: 1 January 2019 – 30 June 2020
Grant amount: 200.500€
Project name: HEER - Haciendo la evolución in silico de enzimas una realidad

* Ha sido financiado por los Presupuestos Generales del Estado a cargo de la aplicación 27.12.467C.74908

PETases

Funded by Torres Quevedo program from Spanish Ministry of Science and Innovation, the project goal is to investigate and define at the atomic level, the functioning of PETases enzymes, through a specialized software, ZYMEVOLVER. This information will be essential to optimize, in a controlled way, these enzymes in the multiple processes where they can be applied.

 

Reference: PTQ2018-009837
Start-End Date: 1 November 2019 – 2 May 2022
Grant amount: 111.720€
Project name: Investigación, caracterización y diseño de nuevas enzimas con aplicaciones en la degradación de plásticos no biodegradables.
Collaboration: Massachusetts Institute of Technology (MIT).

Past projects

R&D Team

Emanuele Monza, PhD

Head of R&D

Jesús Seco, PhD

Senior Researcher

Laura Masgrau, PhD

Senior Researcher

Marina Cañellas, PhD

Senior Researcher

Lur Alonso, PhD

Researcher

Ryoji Takahashi, PhD

Senior Researcher

Ferran Sancho Jodar, PhD

Researcher

Want to join the team?
Check the section Careers

R&D Alumni

R&D Visitors

Scientific Publications

*Most relevant

  1. The Methionine-Rich Loop of Multicooper Oxidase McoA follows Open-To-Close Transitions with a Role in Enzyme Catalysis, 2020 – ACSCat
  2. *Enhancing thermostability by modifying flexible surface loops in an evolved high‐redox potential laccase, 2019 – AIChE
  3. *Increasing redox potential, redox mediator activity, and stability in a fungal laccase by computer-guided mutagenesis and directed evolution, 2019 – ACSCat
  4. Kauniolide synthase is a P450 with unusual hydroxylation and cyclization-elimination activity, 2018 – NatComm
  5. The ins and outs of vanillyl alcohol oxidase: Identification of ligand migration paths, 2017 – PLOSCompBio
  6. *Oxidoreductases on their way to industrial biotransformations, 2017 – BioAdv
  7. *Molecular Modeling in Enzyme Design, Toward In Silico Guided Directed Evolution, 2017- Book chapter
  8. *Repurposing designed mutants: a valuable strategy for computer-aided laccase engineering – the case of POXA1b, 2017 – CatSciTech
  9. Mapping the Long-Range Electron Transfer Route in Ligninolytic Peroxidases, 2017 – JPCB
  10. *Simulating Substrate Recognition and Oxidation in Laccases: From Description to Design, 2017 – JCTC
  11. Probing the Surface of a Laccase for Clues towards the Design of Chemo‐Enzymatic Catalysts, 2017 – ChemPlusChem
  12. *Re-designing the substrate binding pocket of laccase for enhanced oxidation of sinapic acid, 2016 – CatSciTech
  13. Asymmetric sulfoxidation by engineering the heme pocket of a dye-decolorizing peroxidase, 2016 – CatSciTech
  14. *Computer-Aided Laccase Engineering: Toward Biological Oxidation of Arylamines, 2016 – ACSCat
  15. Rational Enzyme Engineering Through Biophysical and Biochemical Modeling, 2016 – ACSCat
  16. Synthesis of 1-Naphthol by a Natural Peroxygenase engineered by Directed Evolution, 2016 – CBC
  17. Molecular determinants for selective C25-hydroxylation of vitamins D2 and D3 by fungal peroxygenases, 2016 – CatSciTech
  18. **Insights into Laccase Engineering from Molecular Simulations: Toward a Binding-Focused Strategy, 2015 – JPClett
  19. Steroid hydroxylation by basidiomycete peroxygenases: A combined experimental and computational study, 2015 – AEM
  20. Atomic Picture of Ligand Migration in Toluene 4-Monooxygenase, 2014 – JPCB