Biocatalystsmadeeasier
Evolving enzymes onebyte at a time
Projects
We are continuously innovating and are involved in high-impact R&D projects with international universities, research centers and companies
Scientific Publications
We are committed to expanding the use of computer simulations for discovery and optimization of new biocatalysts
Projects
BRAINZYME-2022
BRAINZYME is an Industrial Development project that aims to create a tech platform -zymBrain- capable of developing enzymes, offering new services to clients, serve society and provide a tool for intelligent decision-making.
Reference: 2021/C005/00150909
Start-End Date: 1 September 2022 - 23 May 2024
Grant Amount: 697,753.65 €
Project Name: ZYMBRAIN
TECNIOSPRING-2021
The ENZIMMO-P project, also known as "Software Development for Biocatalytic Process Optimization", is aimed at upgrading the software used to improve enzymes’ properties, which are later applied to industrial processes.
Reference: ACE026/21/000082
Start-End Date: 25 July 2022 - 24 July 2024
Grant Amount: 136,205.45€
Project Name: ENZIMMO-P
TECNIOSPRING-2020-DOGC-8160
The IDEA-PS project aims to develop a new computational platform capable of identifying enzyme inhibitors in complex formulations used in chemical industry. The software will allow us to make more effective formulations that will save resources, energy and water.
Reference: 3412C2V7T-1
Start-End Date: 1 October 2021 - 31 October 2023
Grant Amount: 135.961,90€
Project Name: IDEA-PS
H2020-MSCA-ITN-2020
Funded by the European Commission, the BioInspireSensing project is a trans-national network for training PhD students in investigating, building, and producing a new generation of bioinspired implantable sensors of pressure, temperature and acidity. New devices will be made of complex hybrid materials, composed of natural molecules and synthetic biopolymers, with the additional properties of being fully biocompatible and bioresorbable.
Reference: 955643
Start-End Date: 1 January 2021 - 31 December 2024
Grant Amount: 2,856,013€
Project Name: BIOINSPIRESENSING
Consortium: Polytechnic University of Catalonia (coordinator), University of Teramo, University of Warsaw, 4Dcell SAS, University of Groningen, VIB-KU Leuven, University of Lausanne, ZYMVOL BIOMODELING SL.
H2020-MSCA-RISE-2018
Funded by European Commission, project goals address current limitations in lignin degradation by generating technological and economical solutions inspired by fundamental research. The project provides a holistic view for the development of biocatalytic processes involved in the valorisation of lignin.
Reference: 824017
Start-End Date: 1 February 2019- 31 January 2023
Grant amount: 970,000€
Project name: B-ligZymes
Consortium: Universidade Nova de Lisboa, Rijksuniversiteit Groningen, Universita degli studi di Roma Torvegata, Technische Universitaet Braunschweig, MetGen, Inquimae, North Carolina State University, ZYMVOL BIOMODELING SL.
Scientific Publications
*Most relevant
- Enzyme immobilization studied through molecular dynamic simulations, 2023 – Frontiers in Bioengineering and Biotechnology
- Towards design of drugs and delivery systems with the Martini coarse-grained model, 2022 – QRB Discovery
- Structure- and computational-aided engineering of an oxidase to produce isoeugenol from a lignin-derived compound, 2022 – Nature Communications
- Rational-Guided Improvement of NOV1 Dioxygenase for the Conversion of Lignin-Derived Isoeugenol to Vanillin, 2022 – Biochemistry
- Unveiling Molecular Details behind Improved Activity at Neutral to Alkaline pH of an Engineered DyP-type Peroxidase, 2022-CSBJ
- Distal Mutations Shape Substrate-Binding Sites during Evolution of a Metallo-Oxidase into a Laccase, 2022-ACSCatal
- Computational Enzyme Design at Zymvol, 2022 – Enzyme Engineering
- Survey of Current Commercial Enzyme and Bioprocess Service Providers, 2020 – AppBio
- The Methionine-Rich Loop of Multicooper Oxidase McoA follows Open-To-Close Transitions with a Role in Enzyme Catalysis, 2020 – ACSCat
- *Enhancing thermostability by modifying flexible surface loops in an evolved high‐redox potential laccase, 2019 – AIChE
- *Increasing redox potential, redox mediator activity, and stability in a fungal laccase by computer-guided mutagenesis and directed evolution, 2019 – ACSCat
- Kauniolide synthase is a P450 with unusual hydroxylation and cyclization-elimination activity, 2018 – NatComm
- The ins and outs of vanillyl alcohol oxidase: Identification of ligand migration paths, 2017 – PLOSCompBio
- *Oxidoreductases on their way to industrial biotransformations, 2017 – BioAdv
- *Molecular Modeling in Enzyme Design, Toward In Silico Guided Directed Evolution, 2017- Book chapter
- *Repurposing designed mutants: a valuable strategy for computer-aided laccase engineering – the case of POXA1b, 2017 – CatSciTech
- Mapping the Long-Range Electron Transfer Route in Ligninolytic Peroxidases, 2017 – JPCB
- *Simulating Substrate Recognition and Oxidation in Laccases: From Description to Design, 2017 – JCTC
- Probing the Surface of a Laccase for Clues towards the Design of Chemo‐Enzymatic Catalysts, 2017 – ChemPlusChem
- *Re-designing the substrate binding pocket of laccase for enhanced oxidation of sinapic acid, 2016 – CatSciTech
- Asymmetric sulfoxidation by engineering the heme pocket of a dye-decolorizing peroxidase, 2016 – CatSciTech
- *Computer-Aided Laccase Engineering: Toward Biological Oxidation of Arylamines, 2016 – ACSCat
- Rational Enzyme Engineering Through Biophysical and Biochemical Modeling, 2016 – ACSCat
- Synthesis of 1-Naphthol by a Natural Peroxygenase engineered by Directed Evolution, 2016 – CBC
- Molecular determinants for selective C25-hydroxylation of vitamins D2 and D3 by fungal peroxygenases, 2016 – CatSciTech
- **Insights into Laccase Engineering from Molecular Simulations: Toward a Binding-Focused Strategy, 2015 – JPClett
- Steroid hydroxylation by basidiomycete peroxygenases: A combined experimental and computational study, 2015 – AEM
- Atomic Picture of Ligand Migration in Toluene 4-Monooxygenase, 2014 – JPCB
Enzyme immobilization studied through molecular dynamic simulations
2023 - Frontiers in Bioengineering and Biotechnology
Computational Enzyme Design at Zymvol
2022 - Enzyme Engineering