In a brief 30-minute reaction, the top performing enzyme achieved a 63% conversion to the desired chiral alcohol and delivered perfect stereoselectivity, meeting the stringent purity requirements for pharmaceutical ingredients.
Identifying a high-performing KRED for API synthesis
Increasing Success Rates with Early Feasibility Prediction
The introduction of “Feasibility Assessments” —a rapid, preliminary study designed to predict a project’s chances of success before any major investment— led to our overall project success rate soaring from 53% to 85%, providing a level of transparency and risk mitigation previously unheard of in the industry.
From 1.5 Billion Sequences to High-Performing Enzymes in 2 Months
The entire discovery-to-validation cycle was completed in a fraction of the time required for traditional approaches, dramatically de-risking the R&D process, lowering costs, and accelerating the timeline for bringing new products to market.
Delivering a 17x Specificity Boost in 6 Months
After five intensive rounds of directed evolution, a leading biotech company had achieved an 8x increase in enzyme activity and a 12x increase in enzyme specificity. However, they had reached a plateau.
Improving Artificial Enzyme Performance with Distal Mutations
By screening a small number of mutant enzymes, the team discovered two individual single distant mutations —located more than 11 Å from the active site— that significantly improved the enzyme’s properties.
Simpler oxygenated product synthesis by altering enzyme specificity
In only one month, we went from a highly specific bacterial peroxygenase to a versatile enzyme capable of hydroxylating both indole and thioanisole, two substrates it previously could not act on.
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Create new products and processes, adapt existing ones or develop completely new biochemistry. Zymvol is here to guide you in any stage of your journey.
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