Experimental validation confirmed that 9 sequences out of 22 (40% hit rate) exhibited activity against at least one of the five substrates tested, demonstrating our approach’s ability to identify functional biocatalysts.
Discovering 9 novel ketoreductases from a 250k metagenomic library
Breaking IP barriers in API production
The enzyme engineering campaign yielded a lead candidate that significantly surpassed existing benchmarks. Experimental validation confirmed that Zymvol’s top hit delivered 10x higher activity than the leading patented enzyme, as well as 99% e.e.
Identifying a high-performing KRED for API synthesis
In a brief 30-minute reaction, the top performing enzyme achieved a 63% conversion to the desired chiral alcohol and delivered perfect stereoselectivity, meeting the stringent purity requirements for pharmaceutical ingredients.
From 1.5 billion sequences to high-performing enzymes in 2 months
The entire discovery-to-validation cycle was completed in a fraction of the time required for traditional approaches, dramatically de-risking the R&D process, lowering costs, and accelerating the timeline for bringing new products to market.
Start your Evolution
Create new products and processes, adapt existing ones or develop completely new biochemistry. Zymvol is here to guide you in any stage of your journey.
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